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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
DRD3
All Species:
6.97
Human Site:
S257
Identified Species:
15.33
UniProt:
P35462
Number Species:
10
Phosphosite Substitution
Charge Score:
0.2
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P35462
NP_000787.2
400
44225
S257
L
E
L
K
R
Y
Y
S
I
C
Q
D
T
A
L
Chimpanzee
Pan troglodytes
Q5IS72
400
44218
S257
L
E
L
K
R
Y
Y
S
I
C
Q
D
T
A
L
Rhesus Macaque
Macaca mulatta
XP_001085336
414
47327
E262
L
S
S
T
S
P
P
E
R
T
R
Y
S
P
I
Dog
Lupus familis
XP_545106
447
49572
D257
I
R
Q
F
S
I
R
D
R
F
P
S
D
A
T
Cat
Felis silvestris
Mouse
Mus musculus
P30728
446
49651
A257
I
R
Q
F
S
I
R
A
R
F
L
S
D
A
T
Rat
Rattus norvegicus
P19020
446
49497
A257
I
R
Q
F
S
I
R
A
R
F
L
S
D
A
T
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
XP_001234083
479
52737
S261
Y
Q
Y
N
T
G
Q
S
S
C
R
R
V
S
L
Frog
Xenopus laevis
P24628
442
49720
P255
V
K
S
N
G
S
F
P
A
D
K
K
K
V
I
Zebra Danio
Brachydanio rerio
Q90WY6
432
49119
S263
E
N
G
H
C
S
S
S
P
G
E
R
K
P
A
Tiger Blowfish
Takifugu rubipres
P53453
463
52101
M259
E
D
V
R
L
C
T
M
I
V
K
S
N
G
S
Fruit Fly
Dros. melanogaster
NP_001014760
461
51513
H303
T
A
L
D
S
S
R
H
A
S
R
I
L
P
D
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.2
54.8
83.6
N.A.
81.8
80.4
N.A.
N.A.
56.7
50.9
34.9
49.6
34.9
N.A.
N.A.
N.A.
Protein Similarity:
100
99.5
65.9
87
N.A.
85.8
85.1
N.A.
N.A.
64
64
52.5
62.2
50.5
N.A.
N.A.
N.A.
P-Site Identity:
100
100
6.6
6.6
N.A.
6.6
6.6
N.A.
N.A.
20
0
6.6
6.6
6.6
N.A.
N.A.
N.A.
P-Site Similarity:
100
100
26.6
13.3
N.A.
20
20
N.A.
N.A.
40
33.3
13.3
33.3
13.3
N.A.
N.A.
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
10
0
0
0
0
0
19
19
0
0
0
0
46
10
% A
% Cys:
0
0
0
0
10
10
0
0
0
28
0
0
0
0
0
% C
% Asp:
0
10
0
10
0
0
0
10
0
10
0
19
28
0
10
% D
% Glu:
19
19
0
0
0
0
0
10
0
0
10
0
0
0
0
% E
% Phe:
0
0
0
28
0
0
10
0
0
28
0
0
0
0
0
% F
% Gly:
0
0
10
0
10
10
0
0
0
10
0
0
0
10
0
% G
% His:
0
0
0
10
0
0
0
10
0
0
0
0
0
0
0
% H
% Ile:
28
0
0
0
0
28
0
0
28
0
0
10
0
0
19
% I
% Lys:
0
10
0
19
0
0
0
0
0
0
19
10
19
0
0
% K
% Leu:
28
0
28
0
10
0
0
0
0
0
19
0
10
0
28
% L
% Met:
0
0
0
0
0
0
0
10
0
0
0
0
0
0
0
% M
% Asn:
0
10
0
19
0
0
0
0
0
0
0
0
10
0
0
% N
% Pro:
0
0
0
0
0
10
10
10
10
0
10
0
0
28
0
% P
% Gln:
0
10
28
0
0
0
10
0
0
0
19
0
0
0
0
% Q
% Arg:
0
28
0
10
19
0
37
0
37
0
28
19
0
0
0
% R
% Ser:
0
10
19
0
46
28
10
37
10
10
0
37
10
10
10
% S
% Thr:
10
0
0
10
10
0
10
0
0
10
0
0
19
0
28
% T
% Val:
10
0
10
0
0
0
0
0
0
10
0
0
10
10
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
10
0
10
0
0
19
19
0
0
0
0
10
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _